Published Research

At UCMI we’re dedicated to furthering advances in medical imaging by conducting world-class research. UCMI’s Researchers have had the following work published recently in peer-reviewed journals.

 

PUBLICATION LINKUCMI RESEARCHERSRESEARCH DESCRIPTIONDATE OF PUBLICATION
Mr Ross Holt

Dr Barbara Laing

Dr Darren Ault

Dr Nick Brown

Dr Rob Parkinson
MRI-guided in-bore biopsy for prostate cancer: what does the evidence say? A case series of 554 patients and a review of the current literature

Over the last 5 years prostate MRI has emerged as a revolutionary imaging modality in diagnosis of prostate cancer. The introduction of prostate MRI has led to the possibility of performing a prostate biopsy while the patient is in the MRI machine (MRI-guided biopsy, MRGB). This study reviewed the imaging and biopsy results of 554 men who underwent a MRGB at the Wesley Hospital. It was found that 80% of patients (443 men) were positive for prostate cancer, and 55% of patients (307 men) had a significant cancer. Most men who had a significant cancer had been deemed highly suspicious for significant cancer by the Radiologist who reported the prostate MRI. Overall, this study demonstrates the value of a MRI-based two-step approach to diagnosis of prostate cancer, including prostate MRI, followed by MRGB if the MRI is suspicious for cancer.

September
2018
Dr Rhiannon McBean

Dr Katrina Newbigin
Radiological appearance of coal mine dust lung diseases in Australian workers

Coal Mine Dust Lung Disease (CMDLD) encompasses a spectrum of lung diseases caused by prolonged exposure to coal mine dust. CMDLD include coal workers' pneumoconiosis (black lung) and silicosis. This review presents high‐resolution computed tomography (HRCT) images from men diagnosed with a CMDLD since the resurgence of these diseases in Queensland in 2015.
September
2018
Dr Katrina Newbigin

Dr Rhiannon McBean

Mr Jacob Keenan
Aortic Valve Calcium Scoring as a Predictor of Paravalvular Leakage in Transcatheter Aortic Valve Replacement

Transcatheter aortic valve replacement (TAVR) is an evolving alternative to surgical aortic valve replacement. Paravalvular leakage is one of the most common periprocedural complications involved in TAVR, leading to insertions of a pacemaker in some patients. Novel cardiac imaging techniques, including aortic valve calcium scoring, are being investigated as a tool in pre-procedural planning for TAVR. Quantification of total calcium burden of the aortic valve has been associated with post–TAVR paravalvular leak. Asymmetrical distribution of disease is an independent risk. Involvement of the non–coronary cusp, rather than total calcium burden is associated with risk for pacemaker insertion. At our imaging centre individual and total aortic valve calcium score is measured in 3-mm thickness-slice computed tomography (CT) images before TAVR using a colour map
August
2018
Dr Nick Brown

Dr Duncan Walker

Dr Rhiannon McBean
Prostate artery Embolisation Assessment of Safety and feasibilitY (P-EASY): a potential alternative to long-term medical therapy for benign prostate hyperplasia

Prostate artery embolisation (PAE) is an emerging treatment for symptomatic enlarged prostates (benign prostate hyperplasia, BPH). BPH is very common condition in men with prevalence increasing with age. The PAE procedure is performed by an Interventional Radiologist and involves blocking the blood supply to the prostate with microsphere, which causes the prostate to soften and shrink, thus relieving symptoms. This study was the first prospective trial to study PAE in Australia and aimed to assess the safety, short-term efficacy and early functional results of (PAE). The results of this study showed PAE is a technically feasible and safe procedure, with excellent short-term efficacy. Follow-up of this cohort to 3 months showed an 80% improvement in both symptoms and quality of life; furthermore 90% of patients had ceased or decreased their dependence on medication for BPH.
August
2018
Dr Katrina Newbigin

Dr Rhiannon McBean
Novel MRI of mediastinal masses: internal differentiation of a thymoma and lymphoma with T1 and T2 mapping

This case report details two middle-aged women who each presented with a tumour of similar size and appearance when assessed with routine imaging. With the application of a novel MRI imaging technique, called T1 and T2 mapping, we were able to differentiate the internal properties of these tumours prior to surgery. Further research into this method may one day lead to “non-invasive biopsy” where tumours can be typed with imaging, rather than requiring analyse of tissue samples taken with invasive methods.
April
2018
Dr Rhiannon McBean

Dr Katrina Newbigin

Mr Rohan Tollenaere
Mid-Cavity Variant Takotsubo Cardiomyopathy—Magnetic Resonance Imaging Findings

Takotsubo cardiomyopathy is a syndrome characterised by abnormalities in heart function which is often brought on by severe stress or shock, giving it the name “broken heart syndrome”. Imaging is an excellent way to diagnose this syndrome, and in the case report described we detail, for the first time, the MRI appearance of a rare form of this syndrome.
April
2018
Dr Nick BrownFirst use of microvascular plugs in Australia for permanent embolisation of small arteries

Micro Vascular Plug System (MVP), are a treatment for small blood vessels in the lungs which are abnormally connected to each other (called pulmonary arteriovenous malformations, PAVMs). If left untreated, patients are at increased risk of serious complications such as stroke. This report describes the first Australian experience with the use of MVP for PAVMs and found that inserting these tiny blood vessel plugs into the PAVM was a feasible, safe and effective treatment.
February
2018
A/Prof David WongInitial multicentre experience of Gallium-PSMA PET/CT guided robot-assisted salvage lymphadenectomy: acceptable safety profile but oncological benefit appears limited

PSMA PET/CT imaging is considered highly sensitive for the detection and staging of prostate cancer. This study investigated prostate cancer patients who had surgery to remove lymph nodes which PSMA PET/CT imaging identified as being cancerous. The results of this study showed that the lymph node surgery was safe, but that one year later few patients were cured of cancer. Overall, this means that PSMA PET/CT doesn’t detect very small lymph nodes which are cancerous (called micro-metastatic disease); meaning that often when surgery is performed these small lymph nodes aren’t removed and a patient’s prostate cancer is not cured.
November
2017
Dr Katrina NewbiginDiffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a rare subtype of premalignant pulmonary carcinoid

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare condition, with approximately 200 cases reported worldwide since its first description in 1992. DIPNECH is believed to be a pre-cancerous condition in which neuroendocrine cells grow in the lungs. When medical imaging is done most patients with DIPNECH have so many small spots of cells in their lungs (nodules) that the Radiologist can not count them ("innumerable"). The cause of DIPNECH is unknown and understanding of the clinical course is limited due to small case series; however, it appears to predominantly affect non‐smoking middle‐aged women. Diagnosis is often delayed with an average length of 10 years of symptoms prior to diagnosis. Here we review the literature and present a case of a 66 year old male who presented with chronic shortness of breath and was diagnosed with DIPNECH.
October
2017
Dr Katrina NewbiginInterim analysis of the resurgence of pneumoconiosis in Australian coal and other underground miners

For many years pneumoconiosis (often called "black lung") was believed to be eradicated in Queensland. In 2015, this myth was dispelled, upheaving the mining and medical communities. Here we present a review of 13 Australian miners recently diagnosed with CWP or silicosis following the re-identification of these diseases. The focus of this small interim review was the medical imaging pattern of these cases with different patterns observed between the two diagnosis sub-types.
October
2017
A/Prof David Wong

Dr Katrina Newbigin
Multi-modality imaging to diagnose isolated cardiac sarcoidosis and determine regional inflammatory activity levels

Cardiac sarcoidosis is a rare disease which can cause cardiac failure and is associated with poor prognosis if untreated. Early diagnosis of cardiac sarcoidosis is of great clinical importance, as treatment with steroids can improve symptoms and survival rates. Here we report how to diagnose cardiac sarcoidosis using a non-invasive diagnostic imaging approach.
October
2017
Dr Katrina NewbiginDramatic Normalization of the Echocardiographic Pulmonary-to-Left Atrial Ratio with Thrombolysis in a Case of Life-Threatening Submassive Pulmonary Emboli

This case reports describes the ECG imaging features of a patient who presented with a massive pulmonary emboli (blot clot in the lungs). With treatment using thrombolysis the patient's symptoms and heart function were improved. One month later the patient had made a full recovery.
August
2017
Dr Barbara LaingDiagnosis in subdural myeloid sarcoma

This case reports describes a patient with leukaemia in remission, who presented at hospital with headache and decline in cognition. On routine imaging it appeared the patient had a haemotoma, which is a blood clot between the skull and brain. However, during surgery the brain surgeon was surprised to find a solid tumour, rather than a haemotoma. Imaging was repeated, this time with the addition of a contrast solution, and the solid tumour could be seen. This case demonstrated the importance of using contrast solution when imaging similar cases.
June
2017
Dr Louise McEwan

A/Prof David Wong
Flourodeoxyglucose positron emission tomography scan may be helpful in the case of ductal variant prostate cancer when prostate specific membrane antigen ligand positron emission tomography scan is negative

PSMA PET/CT is emerging as a useful imaging method for detecting prostate cancer. Here we report cases involving a rare form of aggressive prostate cancer, where results of PSMA PET/CT scanning was unclear, but FDG PET/CT scanning clearly showed the cancer. Overall, the study demonstrates that in some variant forms of prostate cancer, FDG PET/CT is an important imaging method, rather than PSMA PET/CT.
March
2017
Dr Katrina NewbiginRegression of cardiac amyloidosis following stem cell transplantation a comparison between echocardiography and cardiac magnetic imaging in long term survivors

Cardiac amyloidis is the build-up of protein in the heart and is a serious condition with poor survival for patients. This study performed imaging of cardiac amyloidis patients using echocardiography (ECG) and MRI, before and after chemotherapy and stem cells treatment. Following treatment, imaging showed the disease process was partially reversed and that there was a large improvement in patient survival.
January
2017